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Clinical Trials

Doctors who treat breast cancer patients are very excited about an experimental drug that presents a whole new way of knocking out cancer cells.

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Study: 10% of kids improperly vaccinatedupdated: Thu May 03 2012 09:55:00

A new study in Pediatrics finds some parents aren't giving their children routine vaccinations at recommended intervals.

Ethicist: We need safer drugs for our kidsupdated: Thu May 03 2012 09:55:00

What if most of the drugs your doctor gave you were untested, forcing him or her to guess at the correct medication and dosage -- making you an unwitting research subject whenever you took a pill?

The 40-year war on cancerupdated: Fri Dec 23 2011 13:59:00

On December 23, 1971, President Richard Nixon signed the National Cancer Act of 1971 into law. The legislation had tremendous bipartisan support and came at a time of great optimism. Many thought its passage would lead to a cure for cancer within a few years.

Patient, doctors encouraged by ALS trial updated: Wed Sep 28 2011 11:10:00

A little more than two years ago, Ted Harada felt his left leg weakening, and he found himself quickly running out of breath. Doctors first thought he had asthma, but in May 2010 they told him he probably had ALS, or Lou Gehrig's disease.

Experts caution against stem cell treatments abroadupdated: Thu Sep 22 2011 13:30:00

There's great potential in the field of regenerative medicine, but doctors caution against seeking experimental treatments in an unregulated environment.

When the pieces of memory are scatteredupdated: Mon Sep 12 2011 16:45:00

There was cake at one of the last birthdays Robert John Kreitner Jr. would have at the nursing home in Pennsylvania, but the guest of honor didn't open his eyes to see it.

New treatments for psoriasisupdated: Wed Aug 24 2011 07:03:00

John Lisk reports on new treatments for the skin condition known as psoriasis.

No heart risk seen with psoriasis drugupdated: Wed Aug 24 2011 07:03:00

For people with severe cases of psoriasis, the injectable drugs known as biologics can provide much-needed relief from the itchy, flaky skin lesions caused by the disorder.

Are there new treatments for breast cancer?updated: Wed Jun 01 2011 08:05:00

I have inflammatory breast cancer and I have been through chemo and a double mastectomy. They found active cancer cells so the cancer has spread. The oncologist said she didn't think there was anything more they could do for me. I start radiation soon but she didn't think that that would be very helpful either. Is there anything out there that may help me?

Long-term use of bipolar drug questionedupdated: Tue May 03 2011 18:18:00

The growing use of a popular drug in the long-term treatment of bipolar disorder is based largely on a single, flawed clinical trial that may be steering doctors and patients away from drugs with a more established track record, a new review published this week in the journal "PLoS Medicine" suggests.

Are there any treatments for acute myelogenous leukemia?updated: Wed Nov 10 2010 14:49:00

Is there anything currently in trials for the treatment of acute myelogenous leukemia that can help my father, who has had triple-bypass surgery and is 81 years old?

Drug trials give hope to cancer patientupdated: Tue Oct 05 2010 09:48:00

Out of cancer treatment options, John Cossman turns to clinical trials, without which he says he'd have "no hope."

Cancer 'iron man' puts hope in drug trialsupdated: Tue Oct 05 2010 09:48:00

John Cossman's friends call him cancer's iron man. He's had more than 90 radiation treatments and 200 chemo treatments since being diagnosed with head and neck cancer eight years ago.

Avandia and diabetes: Was revolution worth the risks?updated: Fri Jul 09 2010 08:50:00

A decade after critics first accused the Food and Drug Administration of downplaying side effects from Avandia, the agency says it will reveal on Friday the data it is reviewing ahead of an advisory panel meeting about the safety of the popular diabetes drug.

Fortune: Pharma using Facebook to find human clinical trial subjectsupdated: Tue Jun 29 2010 11:30:00

Let's say you're one of the millions of Facebook users who logs into the site for a minute to reconnect with friends. Maybe you're taking a break from a big project at work, or settling in for an evening of couch surfing. Maybe, sadly, you have cancer, diabetes, or some other ailment. That's when you first notice it: A Facebook ad looking for people to take part in a clinical trial -- in your age range, with your illness, living in your town.

Bipolar woman speaks on mental illnessupdated: Mon Jun 21 2010 09:26:00

Michele Madonna Lindsey, a bipolar manic depressive, discusses what it takes to cope with the mental illness.

Stem cell medical breakthrough?updated: Tue May 04 2010 08:52:00

CNN's Dr. Sanjay Gupta reports on a new stem cell clinical trial that is making history.

Stem cell treatment goes from lab to operating roomupdated: Tue May 04 2010 08:52:00

Imagine having your back cut open, part of your spine removed, a stabilizing device that resembles a mini oil rig mounted on your back, the outer membrane of your spinal cord sliced open and experimental stem cells injected into it -- all for the advancement of science because it's not expected to benefit you.

Nicotine vaccine effective in early testsupdated: Thu Apr 22 2010 15:16:00

A vaccine that could help people stop smoking is showing promise in early clinical trials, researchers announced this week at a national meeting of addiction specialists.

Vaccine may shift odds against deadly brain cancerupdated: Thu Mar 04 2010 10:31:00

The first week of each month, Karen and Jerry Vaneman pack their car for a four-hour drive from Asheville, North Carolina, to the medical complex at Duke University. Inside the Preston Robert Tisch Brain Tumor Center, Karen waits patiently as a parade of doctors and technicians pokes and prods, taking samples of all kinds. On this day alone, she gives 21 vials of blood.

Screening for prostate cancer? Patients should decideupdated: Wed Mar 03 2010 12:36:00

This week, the American Cancer Society releases updated prostate cancer screening guidelines. The guidelines say "men should discuss the uncertainties, risks and possible benefits of screening for prostate cancer before deciding whether to be tested."

First U.S. stem cells transplanted into spinal cordupdated: Thu Jan 21 2010 15:01:00

For the first time in the United States, stem cells have been directly injected into the spinal cord of a patient, researchers announced Thursday.

Stem cell therapies for hearts inching closer to wide useupdated: Mon Jan 18 2010 14:24:00

If you've just had your first heart attack, doctors may one day be able to reverse the damage done with stem cell therapy.

Trial drug may help smokers kick buttsupdated: Mon Nov 09 2009 14:23:00

When Katherine Frazier was a teenager in Silver Spring, Maryland, back in the '60s, smoking was the "in" thing to do. She thought it was glamorous. She thought it was cool. Her friends smoked, her parents smoked, and at the time, no one knew that smoking tobacco could kill you.

Vaccine trial under wayupdated: Mon Nov 09 2009 14:23:00

Reggie Aqui reports on a new vaccine that could help people quit smoking for good.

Swayze's 2 years with pancreatic cancer 'an accomplishment'updated: Wed Sep 16 2009 18:15:00

Actor Patrick Swayze's achievements include several feature films such as "Dirty Dancing" and "Ghost," as well as living with advanced pancreatic cancer for longer than most patients.

LKL: Swayze was lovedupdated: Wed Sep 16 2009 18:15:00

Larry talks with his guests about their remembrances of the late Patrick Swayze.

Cancer spread to liver responds to experimental treatmentupdated: Tue Jun 23 2009 13:55:00

When Linda Campbell of Lexington, North Carolina, started to lose her vision in winter 2000 she knew something was wrong. After a diagnosis of ocular melanoma, a rare cancer, she went through numerous treatments to save her eye. Despite one recurrence, by 2007 Campbell was pretty sure she had beaten the odds. That was until last year, when her doctors found lesions on her liver. Her melanoma had spread.

Bioengineered bugs could lead to malaria vaccineupdated: Thu Apr 23 2009 16:58:00

For most Americans, mosquitoes are pests whose bites leave behind itchy bumps. But in other parts of the world, mosquitoes carry a disease called malaria that kills more than a million people each year.

Growth of clinical trial outsourcing raises issuesupdated: Wed Feb 18 2009 21:20:00

The practice of moving research involving human subjects from wealthy countries to less wealthy countries has grown in recent years, raising a number of ethical and scientific issues that need to be addressed, researchers said in a journal article Wednesday.

Doctors admit prescribing placebosupdated: Fri Jan 30 2009 17:43:00

Placebos, or "sugar pills," have been used in medicine since ancient times. Today, most placebos are given in clinical trial studies for new drugs. A study in the January 2008 issue of the Journal of General Internal Medicine found that 45 percent of Chicago, Illinois, internists report they have used a placebo for patients at some time during their clinical practice. Only 4 percent of those admitted they were giving a placebo.

Study: Pill as good as chemo for some patientsupdated: Fri Nov 21 2008 16:03:00

A cancer treatment that comes in a pill is as effective as the standard chemotherapy for lung patients who had previously been treated for their cancer, according to a study released Thursday. Should Clinical Trials Be Outsourced? updated: Thu Aug 07 2008 13:00:00

Western drug makers are increasingly outsourcing human clinical drug trials -- and India is getting the lion's share of the market. Is it putting millions at risk?

Want to be a guinea pig?updated: Thu Jun 26 2008 13:16:00

CNN Medical Correspondent Elizabeth Cohen discusses the risks involved in medical trials. Can Ancient Herbs Treat Cancer?updated: Mon Oct 15 2007 15:00:00

A small California drug company hopes to extract the next cancer cure from Chinese herbs Can a High-Fat Diet Beat Cancer?updated: Mon Sep 17 2007 12:00:00

German researchers are testing a controversial theory, using a low-carb, high-fat diet to help the sickest of cancer patients

CNNMoney: A different way to attack diabetesupdated: Mon Jun 25 2007 00:30:00

Bristol-Myers Squibb and AstraZeneca are working on a new type of diabetes drug, and early-stage test results in humans have showed that the experimental drug, called dapagliflozin, could control blood-sugar levels in diabetics and appears to be safe.

CNNMoney: Tough day for heart drugsupdated: Mon Mar 19 2007 11:05:00

An experimental drug from AtheroGenics and its partner AstraZeneca failed a late-stage clinical trial and is not considered an effective treatment in reducing heart disease, the companies said.

CNNMoney: Pfizer: Once and future (?) kingupdated: Thu Mar 08 2007 11:15:00

There's nothing unusual about a Big Pharma company with outgoing blockbusters and a weak pipeline. Virtually every major drugmaker in America is struggling with this issue.

CNNMoney: New hope for HIV patients from Merck, Pfizerupdated: Wed Feb 28 2007 10:11:00

Merck and Pfizer are giving AIDS patients something to hope for: a new generation of experimental drugs that could prolong their lives.

CNNMoney: FDA wonders if The Pill still works wellupdated: Tue Jan 23 2007 11:38:00

FDA advisors will consider on Tuesday and Wednesday if birth control drugs need more stringent guidelines for safety and effectiveness.

CNNMoney: Novartis poised to lead pharma packupdated: Wed Jan 03 2007 08:57:00

Novartis could be the hottest drug giant in 2007, analysts say, with Schering-Plough and Eli Lilly & Co. not far behind.

CNNMoney: Big Pharma's drug wish list for 2007updated: Thu Dec 21 2006 09:48:00

After a rough couple of years dealing with patent expirations and the often frustrating hunt for new products, drug industry executives would love nothing better than an oracle to predict what products in their labs will become the big blockbuster drugs over the next few years.

CNNMoney: Panel calls for antidepressant warningupdated: Wed Dec 13 2006 21:37:00

Antidepressant drugs need warnings that they may raise the risk of suicidal thoughts and behavior in adults up to age 25, a U.S. advisory panel said Wednesday.

CNNMoney: Merck offers peek into product pipelineupdated: Tue Dec 12 2006 08:38:00

Merck plans to submit three new drugs to the Food and Drug Administration in 2007 and said it will have four experimental drugs in late-stage testing, the company said Tuesday.

CNNMoney: Competition looming for Amgen, Glaxo with blood clot drugsupdated: Mon Dec 11 2006 13:02:00

The biotech Amgen and the drugmaker GlaxoSmithKline announced similar results for experimental blood-clotting drugs and could find themselves locking horns in the near future.

CNNMoney: Heart drug pulled, Pfizer tumblesupdated: Mon Dec 04 2006 10:56:00

Pfizer stock tumbled Monday after the world's biggest drugmaker abruptly pulled the plug on its most important experimental medicine - a drug meant to treat heart disease that instead caused an increase in deaths and heart problems in people taking it in a clinical trial.

CNNMoney: Controversy surrounds failed test drug resultsupdated: Tue Nov 14 2006 11:58:00

Unexpected controversy at the American Heart Association conference over test results of a failed experimental drug pits an independent researcher against a massive drug company and its biotech partner.

CNNMoney: Merck sets sights on new arthritis blockbusterupdated: Fri Nov 10 2006 09:21:00

Merck is experimenting with a new arthritis painkiller that could replace Vioxx, the former billion-dollar blockbuster that has proven to be a liability for the company.

CNNMoney: Big Pharma: Bad time to botch a blockbusterupdated: Fri Oct 27 2006 13:31:00

Hey Big Pharma, listen up: this is NOT the time to be dropping the ball on a blockbuster.

CNNMoney: The battle to treat nerve pain heats upupdated: Wed Oct 18 2006 14:20:00

The market for painkillers for the shooting pain associated with cancer, diabetes and shingles is expected to soar over the next decade, driven by a largely untapped patient pool of millions of Americans.

CNNMoney: Allos profit is two cancer drugs awayupdated: Fri Oct 13 2006 12:29:00

A small, Colorado-based biotech could be the next big winner in the booming cancer drug industry, especially with a recent boost from the FDA, but that depends on the outcome of its risky drug trials.

CNNMoney: Biotech stocks in the dog houseupdated: Mon Oct 02 2006 12:32:00

It wasn't that long ago that fast-rising biotech stocks were selling for boutique prices. Well, those days are done, and biotech's slumping performance this year has put them within reach of the bargain bin.

CNNMoney: Abiomed's artificial heart to get slow startupdated: Thu Sep 14 2006 15:31:00

Abiomed hit a major medical milestone when the FDA approved its artificial heart, but relatively few people are expected to use it and the company isn't likely to see significant sales from its new product at least a couple years.

Cancer researcher: 'This is just a start'updated: Thu Aug 31 2006 20:46:00

Researchers from the National Institutes of Health are fighting cancer by using the immune system to attack tumors. This new approach has had limited success so far, but experts say there is much promise for the future.

Clinical trials offer hope to patients willing to take the risksupdated: Thu Aug 31 2006 17:59:00

Taking part in a clinical trial is like being on a team, and Charlie Hoff almost didn't make the cut.

AIDS attention turns to preventionupdated: Wed Aug 16 2006 13:01:00

During the 25 years of the AIDS epidemic, much of the focus has been on developing a vaccine or treatment, and prevention has sometimes seemed to take a back seat. But this week at the 16th International AIDS Conference in Toronto, the tables are turning.

CNNMoney: Ariad v Lilly, Part II: The next big patent battleupdated: Fri Aug 04 2006 14:19:00

The bell's about to sound for the next round in a patent fight that the entire pharmaceutical industry is watching.

First success reported with small-dose bird flu vaccineupdated: Fri Jul 28 2006 10:57:00

A British company announced this week that it has developed the first effective small-dose bird flu vaccine.

Glaxo claims bird flu breakthroughupdated: Fri Jul 28 2006 01:35:00

A British company has announced that it has developed the first effective small-dose bird flu vaccine.

CNNMoney: Cell Therapeutics' chemo drug gambleupdated: Fri Jul 07 2006 13:20:00

Cell Therapeutics, a small biotech, is betting its future on an experimental drug that could enhance the effects of chemotherapy while reducing its agonizing symptoms.

CNNMoney: Pfizer sued over alleged Lipitor side effectsupdated: Thu Jun 08 2006 08:11:00

Lipitor, the world's top-selling drug from the world's leading pharmaceutical company, has been targeted by two lawsuits blaming it for memory loss and damage to the nervous system.

CNNMoney: Merck wants to raise your cholesterolupdated: Wed May 31 2006 10:14:00

Merck is funding a large-scale study to see if an experimental drug that boosts a certain type of cholesterol can prevent heart attacks and strokes, possibly strengthening its position in the $25 billion cholesterol industry even as a key blockbuster teeters on the brink of patent expiration.

CNNMoney: Drug giants fight for diabetes marketupdated: Wed May 24 2006 08:33:00

The drug giants Merck and Novartis could soon be locking horns for dominance in the multibillion-dollar diabetes sector.

CNNMoney: Canadian Vioxx study challenges Merckupdated: Wed May 03 2006 09:51:00

A Canadian study involving thousands of Vioxx patients concluded they faced the highest risk of heart attack during the first few weeks of taking Merck's arthritis painkiller.

Drug test 'like Russian Roulette'updated: Thu Mar 16 2006 06:19:00

A man who took part in trial tests of a new drug that left six people in serious condition said the experience was "like Russian Roulette."

Drug trial creates 'Elephant Man'updated: Wed Mar 15 2006 04:14:00

Two men are in critical condition in a London hospital and four others are in serious condition after taking part in a clinical trial for a new drug.

CNNMoney: FDA takes a closer look at withdrawn MS drugupdated: Thu Feb 23 2006 13:08:00

The FDA's balancing act between safety and speed is taking center stage with the multiple sclerosis drug Tysabri.

CNNMoney: Luxembourg steel maker files for US IPOupdated: Tue Jan 10 2006 21:37:00

Luxembourg -based steel maker Ternium S.A. on Wednesday filed to raise about $434 million in an initial public offering of 24.8 million shares.

Fortune: Staying the Courseupdated: Mon Nov 14 2005 00:01:00

I WAS GENENTECH'S chief medical officer when we began clinical-trial studies of Avastin in 1997. The hypothesis was that Avastin could stun a tumor--keep it from growing beyond the size of a BB pel...

'Imitate' gives way to 'innovate'updated: Wed Sep 07 2005 01:02:00

The business proposition has changed dramatically for India's pharmaceutical industry since the beginning of this year.

CNNMoney: A better breast implantupdated: Thu Aug 25 2005 12:33:00

The market dynamic for breast implants could swing dramatically over the next year, and it has a lot to do with a new implant with a consistency that's been compared to Gummy Bears.

CNNMoney: Vertex stock soars on upgradeupdated: Fri Aug 19 2005 13:38:00

The stock price for Vertex Pharmaceuticals surged following an upgrade from J.P. Morgan on Friday, as the small drug maker moves ahead with testing on an experimental treatment for hepatitis C.

Robot workout for stroke sufferersupdated: Mon Aug 15 2005 06:49:00

MIT scientists are hoping to create a "workout area" for stroke sufferers that incorporates smart therapeutic robots to help patients regain movement of their bodies.

FSB: The Cuban Cureupdated: Wed Jun 01 2005 00:01:00

It was a hot summer afternoon in Havana. Executives from CancerVax, a small biotech firm based in Carlsbad, Calif., waited nervously to sign a landmark licensing agreement with the Cuban government...

CNNMoney: Drug companies draw criticismupdated: Tue May 31 2005 06:09:00

Some major drug manufacturers, including Dow components Merck & Co. and Pfizer, are being criticized in a published report for failure to disclose results from clinical studies on new medicines.

CNNMoney: Rheumatoid arthritis drugs get tractionupdated: Wed Apr 06 2005 09:11:00

Two drug candidates that would reduce the symptoms of rheumatoid arthritis have passed testing, announced drug manufacturers Human Genome Sciences, Roche, Genentech and Biogen Idec on Wednesday, offering hope where arthritis treatments have raised health concerns.

FDA backs away from antidepressant warningupdated: Wed Feb 09 2005 15:18:00

The Food and Drug Administration has backed off its warning that antidepressants such as Zoloft, Paxil and Prozac can cause suicidal actions among children and teens taking those prescription drugs.

Companies pledge more transparency in drug trialsupdated: Sun Jan 09 2005 21:32:00

Facing growing scrutiny over the safety of their products, the leading global drug companies last week pledged to disclose more information about their clinical trials. Adoption of this new policy, however, is completely voluntary and does not require any disclosure of exploratory trials.

Documents: Prozac use reports more likely to list suicideupdated: Tue Jan 04 2005 13:07:00

Internal documents from Eli Lilly and Co. appear to indicate that the drug maker had data more than 15 years ago showing that adverse-effect reports for Prozac were far more likely to list suicide attempts and violence than reports for other antidepressants.

FDA urges limits on Celebrex, Bextraupdated: Thu Dec 23 2004 15:10:00

The Food and Drug Administration issued a public health advisory Thursday, recommending doctors limit the use of Pfizer Inc.'s Celebrex and Bextra to patients who can't take other pain medicines.

CNNMoney: Pfizer cites Celebrex heart attack riskupdated: Fri Dec 17 2004 09:36:00

Pfizer Inc. said Friday it had no plans to pull the popular painkiller Celebrex off the market despite data showing that patients using the drug in a long-term cancer study had more than double the risk of a heart attack.

CNNMoney: Merck sees 1Q profit slippingupdated: Thu Mar 04 2004 10:12:00

Merck & Co. Inc. said Thursday it expects its first-quarter earnings per share to decline, hurt by a dearth of new drugs and the spin-off of its pharmacy benefits unit.

CNNMoney: Tech stocks finish higherupdated: Mon Mar 01 2004 15:49:00

Technology stocks finished higher on Monday after manufacturing data hinted that a turnaround in hiring may be on the horizon and boosted investors' expectations for Friday's crucial jobs report for February.

Business 2.0: The Pill that Will Make You Thin Pharma companies large and small are in hot pursuit of the blockbuster of all blockbusters--a dupdated: Mon Mar 01 2004 00:01:00

As hospital food goes, the menu was positively four-star: chicken curry and rice, fruit salad, chocolate drops, and candy bars. For the two dozen hungry test subjects gathered for a meal at London'...

CNNMoney: Stock picks by the prosupdated: Wed Feb 04 2004 14:02:00

With the flow of fourth-quarter earnings reports slowing to a trickle, investors may be looking for few investment ideas, and two money managers appeared on CNNfn to suggest some stocks in the mining, media and petroleum sectors.

FSB: The Miracle Hunter How Elizabeth Corsi turned a drug nobody wanted into a company that could soon gross $500 million--and prolonupdated: Sun Feb 01 2004 00:01:00

For Ernest Lynton, the diagnosis was a death sentence. He had cancer of the pancreas, a disease so lethal that he would be lucky to live six months. Surgery had failed--the tumor was too large--and...

Fortune: Reefer Sanityupdated: Mon Nov 24 2003 00:01:00

If you're among those of us who did inhale, you'll recall one of the weed's enjoyable side effects: intense attacks of the munchies that sent you scurrying for baked beans and Moon Pies faster than...

Business 2.0: End Of The Crusade VaxGen dreamed big and lost big when its AIDS vaccine failed a multimillion-dollar clinical trial. At that poupdated: Wed Oct 01 2003 00:01:00

One day last February, a 60-year-old man with sandy-gray hair checked into the Ritz-Carlton in Half Moon Bay, Calif., under the assumed name Fred Drake. Before entering a windowless conference room...

Fortune: King Of The Pill Pfizer is the biggest drug company ever. Can it become the best?updated: Mon Apr 14 2003 00:01:00

A clutch of Pentagon officials sat around a conference table on the 30th floor of Pfizer's Manhattan headquarters last month, firing questions at David Shedlarz, the CFO. They had come seeking stra...

Fortune: The Killer Bug A lethal new mutation of the wily staph bacterium is proving resistant to the best antibiotic in the drawer. Can updated: Mon Sep 30 2002 00:01:00

First it was kidney failure and diabetes. Then, for a 40-year-old Michigan woman this June, the diabetes led to foot ulcers and gangrene. One toe had to be amputated, then a second, then a third.

Fortune: Hatching a DNA Giant It used to take years to find a single gene. Now Millennium Pharmaceuticals, a leader in the booming field updated: Mon May 24 1999 00:01:00

From the look of its stock-price chart, you'd think Millennium Pharmaceuticals was a hot Internet company. Its share price almost quadrupled between September and February--nearly matching Yahoo's ...

Fortune: The Selling of Impotence Impotence is a much bigger problem than doctors used to think, and new pills are on the way to treat itupdated: Mon Mar 16 1998 00:01:00

A new chapter in the history of impotence began in 1983, when a 57-year-old British physician named Giles Brindley stepped from behind the lectern at a Las Vegas medical conference, dropped his pan...


Fall often has an invigorating effect on biotechnology stocks. Clinical trial results pour out of the scientific and investment conferences that tend to bunch between September and January. The Str...

Fortune: Speeding Help From Lifesaving Drugs updated: Mon Apr 13 1987 00:01:00

When Wellcome's AZT emerged as the most promising anti-AIDS drug, patients clamored for it despite its experimental status (FORTUNE, September 15). In March the Food and Drug Administration announc...

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